How does fructose affect gout?
Fructose is metabolized in the liver where it accelerates purine breakdown, directly raising uric acid levels — independently of dietary purine intake. High fructose intake (>5g/100g) is now recognized as a significant gout risk factor alongside high purine foods.
Which fruits are worst for gout?
Fruits with over 5g of fructose per 100g pose the highest risk. Our database identifies 111 high-fructose items. Sweet apples, grapes, mangoes, and fruit juices concentrate fructose and may trigger flares despite having low purines.